Vitamin D and its metabolites have a significant clinical role because of their inter-relationship with calcium (Ca) homeostasis and bone metabolism. Second, in the kidney on carbon 1 to form 1,25-OH(2)D. First, in the liver on carbon 25 to form 25-hydroxyvitamin D (25-OHD). Vitamin D that is synthesized in the skin via photo-isomerization or ingested in the diet via intestinal absorption is biologically inert and requires 2 successive hydroxylations. Calcitriol (1,25-dihydroxycholecalciferol ) is the biologically active form of vitamin D found in the body. The term vitamin D also refers to metabolites and other analogs of these substances. Vitamin D (calciferol) refers to a group of lipid-soluble prohormones the 2 major forms of which are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Aetna considers measurements of serum 25-hydroxyvitamin D experimental and investigational for routine preventive screening.
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